Vaccaro, V., Devine, M
They observed that metformin could downregulate the expression of MMP-9/MMP-2 and mTOR while upregulating the expression of protein kinase B and adenosine monophosphate-activated protein kinase (AMPK), thereby inhibiting ovarian granulosa cells dysfunction and promoting their recovery of follicle function ( in vitro studies utilizing human granulosa tumor-derived cell models demonstrates that metformin intervention effectively downregulates multiple components of the LPS-activated inflammatory cascade, including LPS-induced miR-670-3p , NOX2 , NLRP3 , ASC , and GSDMD-N , as well as reducing cellular caspase-1 activity, ROS production, and secretion of inflammatory factors
106 WangX
Novel delivery systems: Explore novel delivery systems such as liposomes and nanoparticles to enhance the retention time of polypeptides in the skin and improve their therapeutic effects
LF was first found in cows milk, and human LF, consisting of 710 amino acids, has a molecular weight of about 80 kDa
A deficiency may cause hair loss, but extra B12 only helps if levels are low
