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The first being our selection of animals slated for euthanasia for the study, which resulted in our use of several sub-strains of mice (all on a C57BL/6 background), and limited our ability to control early life experiences

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39 controls were females including 36 Caucasians, two African-Americans, and one Hispanic

Interactions between these cells with a myriad of growth factors and cytokines derived from vitreous contact and breach of the bloodretinal barrier trigger a cascade of downstream cellular processes, including EMT, chemotaxis, proliferation, excessive extracellular matrix deposition, and cellular migration, leading to the formation of contractile fibrotic membranes and the overt loss of the retinal architecture [280]

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