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Additionally, confinement triggers resistance to chemotherapeutics [198] and to programmed cell death triggered by loss of adhesion (aka anoikis) [199] which in turn facilitates breast cancer metastasis [199]

Published findings describe effects on genes associated with antioxidant response (Nrf2 pathway), DNA repair mechanisms, ubiquitin-proteasome pathway components, and inflammatory signaling cascades

doi: 10.2478/v10036-007-0009-z

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Its effects are supported by decades of dermatological research and clinical application