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4 weeks (12 vials): 36 mL 1 bottle 8 weeks (23 vials): 69 mL 1 30 mL bottle Alcohol Swabs One for the vial stopper + one for the injection site each time

Regular monitoring of fasting glucose, fasting insulin, HOMA-IR, and HbA1c is suggested to monitor changes and refine dosing or lifestyle plans

However, folate supplementation can mask these haematological changes whilst neurological damage continues, highlighting the importance of checking B12 status before commencing folate therapy

The doses are also for a shorter duration and under medical supervision

doi: 10.1016/j.proche.2016.03.092 16 BaldetP.ColasF.BettezM

Due to the second assumption of the MR approach, we also searched for potential pleiotropy in the PhenoScanner v2 database ( p = 1 105)