Role of peroxisomes as a source of reactive oxygen species (Ros) signaling molecules
Under GSH-depleted conditions, GSH-conjugation was two- and three-fold higher in GSTP1 -transfected cells compared to mock-transfected cells, for AQ-QI and DEAQ-QI respectively
Amino acids 710-863 of GspD were expressed as a C-terminal fusion to the glutathione S-transferase protein (GST-GspD C-term) in E
INTRODUCTION As one of the driving forces behind the cellular detoxification machinery, glutathione S -transferases (GSTs) and especially the pi class glutathione S -transferase P1 (GSTP1) is currently in the focus of the cancer research community, evaluating the relevance of GSTP1 epimutations for cancer development and its potential as a major epigenetic cancer biomarker
alcohol exposure to environmental toxins (pollution, pesticides, plastics) high or chronic emotional stress circadian rhythm dysregulation (poor sleep) lack of exercise infections lack of antioxidant intake Important note
In high concentrations, this may result in cellular toxicity [3-6] and has the potential to be neurotoxic [7]