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Hundreds of genes responsible for synaptic transmission, learning, and behavior are deregulated in CdLS patients [391]

Based on the fact that the carboxyl moiety of ibuprofen binds to Arg-120 and Tyr-355 without extending into the side pocket, it was hypothesized that making the carboxyl group longer by adding larger, more rigid groups with hydrogen-bonding functions could enhance the selectivity of ibuprofen while maintaining its ability to reduce pain and inflammation

Evaluation of anti-inflammatory effect ofWithania somniferaroot on collagen-induced arthritis in rats