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In hippocampal neuron cultures, Dihexa was reported to induce spinogenesis and synaptogenesis at picomolar concentrations the basis for the widely-cited seven orders of magnitude more potent than BDNF potency figure

Breaking the code of DNA binding specificity of TAL-type III effectors

(PubMed) McMillan M, Spinks EA, Fenwick GR

In addition, both preclinical and clinical literature often underrepresent females, limiting insights into sex-specific immunometabolic and hormonal modulators of treatment response (Seyedinia et al., 2023

CP: Data curation, Validation, Writing review & editing, Funding acquisition, Writing original draft, Supervision

The makers of DAXI, Revance, have created an injectable that can last up to twice as long as conventional neuromodulators like Botox, Jeuveau, Xeomin, and Dysport