glutathione for liver disease and disulfide sensitizes hepatocytes to TNFα-mediated cytotoxicity via IKK-β S-glutathionylation: a potential mechanism underlying non-alcoholic fatty Dysregulation of glutathione synthesis in – Frontiers | Glutathione: Pharmacological aspects

[2] This gives it a very large surface area for its volume, up to 3000 square metres per gram

These reactions are called oxidative stress

Therefore, mechanical and gravitational forces can alter a number of processes, including gene expression, signalling, adhesion/migration properties, proliferation (91), differentiation (92) and apoptosis (9395), as well as the way that cells organize themselves into three-dimensional (3-D) structures (constructs, tissues, and organs) (96)

PLoS ONE 6 , e25959 (2011)

Oxidative stress is an imbalance between the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and the bodys antioxidant defenses, which can't effectively neutralize these reactive compounds

M.WeiQ.ZhangY.et al