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In May 2007, Pfizer announced that NICE recommended CHAMTIX (varenicline) for use in the UK's National Health Service for adult smokers wishing to quit

They found strong associations between smoking and cancer, so researchers followed up, beginning more studies in the early 1950sthe research that eventually led to the surgeon generals report

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The DCF were treated through an ethanolic extraction, a bleaching in sodium hypochlorite, followed by an alkaline deacetylation, and converted into NCC by sulfuric acid hydrolysis