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The less cumulative room temperature exposure, the better the potency over the life of the vial

The "minimal initial benefit" group (approximately 5-10% of users) reported limited improvements during treatment making discontinuation effects irrelevant, typically explained by inadequate product quality with degraded or low-concentration GHK-Cu, inappropriate application technique reducing absorption, unrealistic expectations exceeding what any topical can achieve, severe underlying pathology requiring medical intervention beyond cosmetic peptides, or individual non-responsiveness to copper peptide treatment for genetic or physiological reasons

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PLoS One, 12(7), e0288888.

W.et al (1996)

doi: 10.20402/ajbc.2016.0078 141