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The main symptoms are amnesia (both retrograde and anterograde) and confabulation, or distorted memories that the patient is confident in despite being bizarre or false

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These include pericyte degeneration or reduction in pericyte coverage [54, 55], basement membrane alterations [56], and astrocytic end-feet detachment from vascular basement membrane

Furthermore, PQQ functions as an antioxidant

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The two most important clinical trials on vitamin E are the Cambridge Heart Antioxidant Study (CHAOS) and Heart Outcomes Prevention Evaluation Study (HOPE)