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Certain risk factors make you more susceptible to stroke, including: an unbalanced diet high in salt, saturated and trans fats, and cholesterol physical inactivity heavy alcohol use tobacco use a family history of stroke being assigned female at birth increasing age race or ethnicity, such as being African American, Alaska Native, or American Indian Certain medical conditions can also increase your risk of stroke, including: a previous stroke or TIA high blood pressure high cholesterol diabetes carrying too much excess weight heart disorders, such as coronary artery disease heart valve defects enlarged heart chambers and irregular heartbeats sickle cell disease diabetes blood clotting disorder patent foramen ovale The complications after a stroke can vary, depending on which parts of the brain have experienced severe damage