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Weight of evidence: Overall evidence is Low-Moderate: multiple animal studies and a growing number of small clinical trials suggest benefits across gutbrain signaling, social and behavioral domains, gastrointestinal symptoms, and neurophysiological patterns, yet most human studies rely on caregiver-reported outcomes, lack biomarker integration, and seldom control for diet, comorbidities, or baseline microbiome composition

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Pregnant or breastfeeding women, and those planning to become pregnant, should not use this treatment

doi: 10.1016/j.jep.2023.116305 111 ZhouCHuangJLiQZhanCXuXZhangXet al

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The influence of age on the 24-hour integrated individuals