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As an example, miR-378 and miR-132 have been shown to increase the survival of luteal cells and progesterone synthesis by targeting pro-apoptotic genes and increasing the expression of STAR, respectively (104)

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Glossary GC gastric cancer HER2 human epidermal growth factor receptor 2 CPS combined positive score PD-L1 programmed cell death 1 ligand 1 FDA food drug administration TCM traditional Chinese medicine DHD4 DNA-binding protein 4 ABC ATP-binding cassette P-gp P-glycoprotein PI3K phosphatidylinositol-3-kinases Akt protein kinase B mTOR1/2 mammalian target of rapamycin complex 1/2 MRP1 multidrug resistance-associated protein 1 Bcl-2 B-cell lymphoma-2 MOMP mitochondrial outer membrane permeabilization BALF1 bamH1 A fragment leftward reading frame 1 TNF tumor necrosis factor NF B nuclear factor kappa-beta ANXA1 annexin A1 HULC highly up-regulated in liver cancer FoxM1 forkhead box protein M1 ATG5 autophagy-related protein 5 ROS reactive oxygen species MDA malondialdehyde GSH glutathione Keap1 kelch-like ECH-associated protein 1 Nrf2 NF-E2-related factor 2 DDR DNA damage response NER nucleotide excision repair PARP1 Poly (ADP-Ribose) polymerase 1 BER base excision repair ERCC excision repair cross-complementing gene TME tumor microenvironment CAFs cancer-associated fibroblasts SDF-1 stromal cell-derived factor-1 TAMs tumor-associated macrophages MSCs mesenchymal stem cells MDR1 multi-drug resistance 1 EMT epithelial-mesenchymal transition TGF transforming growth factor Rab31 Ras-related protein 31 MUC-1 mucin 1 WTAP wilms tumor 1 associated protein ADAR1 adenosine deaminases acting on RNA1 AZIN1 antizyme inhibitor1 CSC cancer stem cell AKAP-L8 PRKA kinase anchor protein 8L SCD1 stearoyl-CoA desaturase 1 MT1M metallothionein 1 M IGF2BP1 IGF2 mRNA binding protein 1 KHDRBS3 KH domain-containing RNA-binding signal transduction-associated protein 3 GLI1 glioma-associated oncogene homolog 1 SOX SRY-box transcription factor FUBP1 far upstream element-binding protein 1 MCM10 maintenance complex component 10 GRP75 glucose-regulated protein 75 NRP1 neuropilin 1 LDHA lactate dehydrogenase A ROR regulator of reprogramming HMGA2 high mobility group protein A2 TRIM14 tripartite motif 14 Dvl2 dishevelled 2 PIP3 phosphatidylinositol 3,4,5-trisphosphate FOXO forkhead box O PTEN phosphatase and tensin homolog deleted on chromosome 10 SIRT1 sirtuin1 KRAS kirsten rat sarcoma virus oncogene homologue DPD dihydropyrimidine dehydrogenase MAPK mitogen-activated protein kinases ERK extracellular signal-regulated kinase JNK c-Jun N-terminal kinase GRB growth-factor-receptor bound protein SOS son of sevenless FGFR fibroblast growth factor receptor ESRRG estrogen-related receptor gamma MDM murine double minute SLC7A11 solute carrier family 7 member 11 GPX glutathione peroxidase DRAM damage-regulated autophagy modulator STAT signal transducers and activators of transcription JAK janus kinase MGMT O6-methylguanine-DNA methyltransferase CIP2A cancerous inhibitor of PP2A TCF T-cell factor LEF lymphoid enhancer-binding factor References 1 BrayFLaversanneMSungHFerlayJSiegelRLSoerjomataramIet al

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