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The complementary MOAs of amylin-analog and GLP-1 receptor agonists appear to be a promising combination therapy with greater weight loss than any other currently approved AOM and the potential to further close the gap with bariatric surgery outcomes

doi: 10.1093/eurheartj/ehv105 177 ZoidakisJMakridakisMZerefosPGBitsikaVEstebanSFrantziMet al

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CagriSema and tirzepatide achieve remarkably similar weight loss (20.4% vs 20.9%) through fundamentally different dual mechanisms -- amylin/GLP-1 versus GIP/GLP-1

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