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This connection to an endogenous protective factor, combined with the breadth of preclinical research showing activity across multiple physiological systems, has contributed to the peptide's popular attention

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Park, Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts

Lancet 2 , 12361240 (1907)

This crucial interaction orchestrates neuronal differentiation, extensive dendritic branching, and heightened synaptic plasticity