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The prevalence and natural history of cor pulmonale in COPD are not yet clear

(2013) www.sciencedaily.com From the article: Previous animal research has demonstrated that castration of rodents is associated with increased pain perception while testosterone replacement reduces pain perception , suggesting an analgesic effect of this sex steroid

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However, the evidence of the impact of CEAID on clinical outcomes in pediatric AIH is equivocal, cannot be extrapolated, and needs further studies [40, 41]