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Environmental Pollutants - persistent compounds in air, water, soil, and food from industrial processes and waste

3.3.2 Iron overload under high glucose promotes ROS generation and triggers ferroptosis HG disrupts iron homeostasis: upregulated TFR1 (iron uptake) and downregulated FTH1 (iron storage) lead to LIP expansion (129, 130)

As a distinct form of regulated cell death, the contribution of ferroptosis to AD pathogenesis and progression warrants further investigation

There was also a significant reduction in mean scores for anxiety, PTSD, and depression (all p 0.001)

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