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B12 (cobalamin) is water-soluble

The master regulators of fatty acid oxidation, Ppara and Ppargc1a , were downregulated by 70% and 69%, accompanied by decreased transcription of genes involved in mitochondrial ( Cpt2 , Acadvl ) and peroxisomal ( Acox1 , Ehhadh ) -oxidation

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This practice limits the ability to confirm whether a specific product batch was independently tested

Isabella et al., 2020)

Differentially expressed proteins (DEPs, |Log 2 FC| 2 and a P-value 0.80) and the mitochondrial signal remained within a robust upper bound (median + 2 median absolute deviation)