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Rangroo Thrane V, Thrane AS, Wang F, Cotrina ML, Smith NA, Chen M, Xu Q, Kang N, Fujita T, Nagelhus EA, Nedergaard M (2013) Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering

Aging is an activity that accompanies life development and is caused by the accumulation of many different insults, including oxidative stress, telomere loss, epigenetic changes, metabolic dysfunction, loss of certain tumor suppressor genes or excessive activation of oncogenes, and mitochondrial dysfunction (McHugh and Gil, 2018)

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E GSH was thereby determined in the IMS, the matrix and the cytosol of strains lacking Glr1 ( glr1 ), or harbouring it only in the cytosol and not in the mitochondrial matrix ( glr1 +cyto GLR1 ) (Figure 3A)