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Finally, from a general point of view, the consistent effect of NSAIDs (24, 25), and thereby, the consistent NSAIDs effects on sphincters failure in rat, and vice versa, the consistent sphincter failure related to NSAIDs, thus, a commonality for both NSAIDs and sphincter failure, could be hardly combined with the quite inconsistent effects of NSAIDs on sphincter pressure in different species so far reported (17-23)

Data in d-i were analysed by partial correlations with age, sex, and comorbidities as covariates