Limitations in Clinical Evidence and Trial Design The current orthopaedic literature on peptides is dominated by animal models, small prospective cohorts, and case series, with very limited RCTs
They are vital for various cellular processes including calcium regulation, cell specialization, DNA and RNA production, cell growth, and also cell death
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Although there is a dearth of bioavailability data for many of the peptide nasal sprays, a study showed that direct intratracheal instillation of a lyophilized powder at high concentrations could achieve reasonable levels of systemic absorption [13]
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