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The expression of pro-ferroptosis genes was also found to be downregulated in the epidermis of mutant mice, and the expression of ferroptosis-suppressing genes such as Gpx4 and Slc7a11 was upregulated

It predominantly affects gene transcription, protein stability, enzyme activity, proteinprotein interactions, protein translocation, and crosstalk with other PTMs

Among these, TNF- production by CGCs can increase senescence of mouse oocytes after ovulation, which may be the cause of oocyte quality decline (106)

Naeini F, Tanha FD, Mahmoudi M, Ansar H, Hosseinzadeh-Attar MJ

Zhang C, Shi Z, Xu Q et al (2023) Astragaloside IV alleviates stroke-triggered early brain injury by modulating neuroinflammation and ferroptosis via the Nrf2/HO-1 signaling pathway

Your clinician should sequence and dose based on your specific presentation and labs not a generic stack protocol