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Transfer of nanocarriers across the BBB and biological effects The main goals for BBB-targeted nanocarriers are at least three-fold, namely increase solubility, enhance brain penetration to reach better therapeutic efficiency, and minimize peripheral side-effects

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Marques J, Fernandez-Irigoyen J, Ainzua E, Martinez-Azcona M, Cortes A, Roncal C, Orbe J, Santamaria E, Zalba G (2022) NADPH oxidase 5 (NOX5) overexpression promotes endothelial dysfunction via cell apoptosis, migration, and metabolic alterations in human brain microvascular endothelial cells (hCMEC/D3)

Stress activates the NeuroEndoMetabolic (NEM) stress response, and your Cardionomic circuit is part of this response