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Given as a single agent, it promotes modest increases in survival, and these effects are enhanced when combined with oxaliplatin and/or irinotecan (FOLFOX, FOLFIRI) 2,3

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Dosage Adjustments Based on Clinical Response Adjusting the dosage is a big part of treating vitamin B12 deficiency

Kuter KZ, Olech , Dencher NA (2019) Increased energetic demand supported by mitochondrial electron transfer chain and astrocyte assistance is essential to maintain the compensatory ability of the dopaminergic neurons in an animal model of early Parkinsons disease

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