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Unaccounted-for hematuria, excruciating and unexplainable bone pain, slow development, and aseptic necrosis of the femoral head indicate the patient's illness is difficult to treat [63]

For a 5 mg vial with a target dose of 250-500 mcg twice daily, adding 2 mL of bacteriostatic water creates a 2.5 mg/mL concentration

[8] Folate was found to be clinically low in approximately 50% of people with CFS in a study by Jacobson et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Pompella A., Emdin M., Franzini M., Paolicchi A

Side effects are minimal and typically include mild soreness at the injection site