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Tobacco use is a leading cause of multiple cancers such as oral cancers, lung, liver, stomach, bowel and ovarian cancers, as well as some types of leukaemia

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"The Global Smoking Epidemic: A History and Status Report"

Generally, the stem attached to tobacco leaf is detached before curing

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Meanwhile, smoking irritates the lungs, making them less effective at clearing out toxins, thus compromising the overall detoxification process