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Vibration-controlled transient elastography VCTE was performed using an M-probe device (Fibroscan

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Under pathologic conditions and in the presence of transforming growth factor beta (TGF-), fibroblasts accumulate in these areas of damage and differentiate into myofibroblasts that secrete collagen and other proteins

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Future directions should prioritize single-cell multi-omics, immune-tumor co-modeling, and real-time clinical feedback systems to unlock the full potential of organoid-informed metabolic therapy in CRC