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In some embodiments, the formulation or composition provides a 0.25:1 ratio, or a 0.5:1 ratio, or a 1:1 ratio, or a 1:2 ratio, or a 1:3, or a 1:4 ratio, or a 1:5 ratio, or a 1:7 ratio, or a 1:10 ratio, or a 1: 15 ratio, or a 1:20 ratio of immediate release and extended release formulations or compositions of a first otic agent and second therapeutic agent, respectively

Proteins , 2016, vol

Such molecules can bind to proteins (which contain hundreds or even thousands of amino acids), altering these proteins function, and therefore serving as biochemical messengers

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10.1007/s100380200047 85 OstromQ