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Increased Interleukin-23 in Hashimotos thyroiditis disease induces autophagy suppression and reactive oxygen species accumulation

Rasmussen J, Dun M, Lund AM, et al

Both PTI and ETI are involved in overlapping downstream immune responses, including activation of mitogen-activated protein kinases (MAPKs), calcium-mediated signaling, reactive oxygen species (ROS) burst, transcriptional reprograming, callose deposition, and biosynthesis of salicylic acid (SA) 2,3

Finally, further efforts in understanding cGAS-STING signaling and autophagy pathways individually as well as their interactions will be instrumental for their targeting in cancer