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The FDA declined to comment on the lawsuit

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Also, estimates of the need for substance use treatment in 2016 are not comparable with estimates prior to 2015 because of the noncomparability of several SUD estimates in 2016 with those prior to 2015

Reynolds American acquired Niconovum in 2009, but David Howard, a spokesperson for Reynolds American Services Company, said the timing of that purchase was not related to FDA regulation

compliers), the results may not generalize to the entire population