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Risk of bias assessment The results of evaluating the quality of the included studies are presented in online Supplementary Fig
In experimental models, it appears to interact with several pathways central to tissue integrity and repair
Quantitative in vitro to in vivo extrapolation (QIVIVE) of atrazine's effects on phosphodiesterase and aromatase mRNA expression in vitro to the rat in vivo based on pharmacokinetic
Whereas, follicular fluid nitrite or nitrate levels were significantly lower in follicles containing mature oocytes that fertilized compared with those that did not [148]
Together, these studies show that inhibition of lipogenic pathways protects from MASLD in multiple models with decreased levels of lipogenic genes, and that GSH depletion through Chac1 overexpression recapitulates similar protective effects by broadly downregulating lipogenic genes
No adverse effects were reported, but rigorous, large-scale trials are lacking, according to NIH
