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Stop using Differin immediately and seek emergency medical help if you have signs of an allergic reaction, such as swelling, hives, or difficulty breathing

Caution: Consult a healthcare professional before using this product if you are trying to conceive, pregnant, or lactating, under the age of 18, or have a medical condition

[18] In this study, the dosage was 500-1000 mg per day for 4 days, then two injections every week for a month, and then one injection every two months as a maintenance dose

In light of current evidence, it seems unlikely that methotrexate alone is capable of inducing chronic liver disease