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In a clinical trial of 15 male subjects (ages 19 to 35 years) who were extensive metabolizers of CYP2D6, bupropion 300 mg per day followed by a single dose of 50 mg desipramine increased the Cmax, AUC, and t1/2 of desipramine by an average of approximately 2-, 5- and 2-fold, respectively

Like many of her supporting turns over the years, De Mornay brings a stark bit of duality to the role, helping make a complex human being out of what might otherwise have been a shrill, patently unlikable character

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He said the place has been in a "soft open" phase in recent days to allow people in the neighborhood to get acquainted with it