Cyanocobalamin : Synthetic form, requires conversion to active B12, longer shelf life, lower cost Methylcobalamin : Bioactive form, immediate utilization, preferred for neurological symptoms, more expensive Hydroxocobalamin: Used for cyanide poisoning, longest-acting Standard dose: 1000mcg/ml Routes: Deep IM (gluteal/deltoid) or subQ (abdominal) Loading phase: Daily/weekly for 1-4 weeks Maintenance: Monthly or every 3 months (hydroxocobalamin) No need for aspiration before injection Oral absorption requires intrinsic factor (absent in pernicious anemia) and healthy ileum
For users that are new to NAD+ Injections, or that prefer to administer a lower dose (max of 50 units weekly), we recommend ordering a 2.5mL vial, as used vials must be discarded after 28 days
Learn more here.
Immediate post-injection care focuses on minimising local reactions: Apply a cold compress to the injection site for 1015 minutes to reduce pain and swelling Avoid massaging or rubbing the area, which can increase bruising Wear loose clothing that doesn't irritate the injection site Gentle movement of the affected limb may help reduce stiffness Hydration and nutrition support general wellbeing during treatment
Nonalcoholic fatty liver disease and metabolic syndrome
Some NHS/ICB guidance notes oral options for dietary-related deficiency, and that long-term injection schedules depend on the cause
