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Synergy was assessed using SynergyFinder 3.0 ( Figures 2A, B )

The combination produced a mean weight reduction of 20.4% under the treatment-policy estimand, versus 3.0% with placebo (-17.3% difference

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In HepG2 ATP7B-KO cells, 7,241 genes met the threshold, with 481 downregulated and 780 upregulated