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Gently stretch the calves, Achilles tendon, and lower leg muscles to relieve tension

Then, they get weekly injections until they start to get better

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Dose separately to preserve stability and potency

This is also the structure Novo Nordisk's own investigational semaglutide+cagrilintide combination used in REDEFINE 1 (Garvey et al., NEJM 2025) both components stepped in parallel through a 16-week ramp rather than introduced together at maintenance

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