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Recent research demonstrates that nicotine exerts much more anti- than pro-inflammatory effects [6] and a recent review of animal literature in HIV and smoking concluded that preclinical studies using nicotine show mild cognitive enhancement, neuroprotective, and possibly anti-inflammatory effects [26]

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A total of 360 patients with severe nicotine dependence, who are willing to voluntarily quit smoking, will be randomly divided into a treatment group (A&AA) or a control group (NRT)

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Overall, 167 children were studied