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Microbiome predicting treatment response and efficacy Gut microbiome profiles are becoming novel biomarkers for predicting patient response to specific treatments, especially in the fields of immunotherapy and antiviral therapy for HCC

Once activated, Akt, one of the main downstream targets of mTORC2 [296], induces inhibitory phosphorylation of the positive regulators of autophagy Beclin-1 [297], forkhead box O3 (FoxO3) [257], and glial fibrillary acidic protein (GFAP) [298]

If a specific treatment is not available or the origin of the male factor infertility is not correctable, other options such as assisted reproductive techniques (ART) may exist