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Misregulation of this process leads to iron overload, which catalyzes the Fenton reaction and exacerbates lipid peroxidation

doi: 10.1111/and.2016.48.issue-7 79 AppletonJ

Naringenin confers multifaceted protective effects in TBI models by targeting neuroinflammation, oxidative stress, mitochondrial dysfunction, and excitotoxicity

Patients who responded to the drug compared to those who did not, had significant differences in baseline levels as well as in the trajectories of several metabolites, including several gutmicrobiota related metabolites, suggesting that the drug exposure might be impacting gut-microbial ecology differently in the two groups

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