doi: 10.1152/ajpendo.00405.2020 31 CuadradoA.RojoA
Applications Applications Glutathione & thioredoxin reductase inhibitor Functions Functions Inhibits glutathione reductase and thioredoxin reductase, IC50s=6.7 and 8.7 M respectively, and impairs mitochondrial function
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Kenjiro Ono et al., 2020, studied the impact of the polyphenolic acids 3-hydroxybenzoic acid (3-HBA), 3,4-dihydroxybenzoic acid (3,4-diHBA), and 3-hydroxyphenylacetic acid (3-HPPA) (derived from gut microbiota-based metabolism of dietary polyphenols) on the brain, and demonstrated their ability to inhibit S oligomerization and mediate aggregate S-induced neurotoxicity in vitro [255]
Women over the age of 60 are more likely to get the condition, as are people who have an autoimmune disease already such as Addisons disease, or people who have family members with the condition
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