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Figure 1 Tumor development and progression depend on the interactions between cancer cells and multiple cell types surrounding the tumor, constituting the tumor microenvironment (TME) ( This review summarizes the data obtained from various studies to explore the benefits of QUE in combination with various chemotherapeutic agents, which manifest in two aspects: enhanced chemotherapy sensitivity and reduced toxic side effects of chemotherapy
Journal Reference: Editorial Team, "FDA Grants Accelerated Approval for Sacituzumab Govitecan in Metastatic Triple-negative Breast Cancer", ADC Review (2020), FDA Press Release, "FDA grants accelerated approval to loncastuximab tesirine-lpyl for large B-cell lymphoma", (2021): Staudacher, Brown, "Antibody drug conjugates and bystander killing: is antigen-dependent internalisation required?", Br J Cancer 117, (2017): 1736-1742,
NF-B is a key modulator in the signaling pathway of Borrelia burgdorferi BmpA-induced inflammatory chemokines in murine microglia BV2 cells
Mercury, in particular, depletes glutathione reserves and weakens glutathione-dependent enzymes
[DOI] [PubMed] [Google Scholar] Kaplowitz N., Kuhlenkamp J., Goldstein L., Reeve J