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2) Chemical haptens and metal ions can interact with human proteins and activate proinflammatory cytokines and trigger T and B cells in particular TH17 which is known for tissue destruction in autoimmune conditions

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animal experiments provide good evidence that GSH is not only safe but also potentially effective, though findings in humans require further clarification

PLoS ONE 7(11)

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4a ) can be classified according to their activation profiles into three distinct phenotypes including resting, activated and alternatively-activated microglia [9, 90]