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Recently, there have been increasing reports showing the existence of 5-hydroxyl (5-OH), 5-cap, 5-triphosphate (5-ppp), 3-phosphate (3-P), 2,3-cyclic phosphate (3-cP), and 3-aminoacyl (3-aa) in eukaryotic sRNAs, which hampered adapter ligation 10,11,12

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