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Asian Journal of Psychiatry, 6 (1), 29-34

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Mechanisms of action Preclinical studies document: Anxiolytic effect without sedation in classical tests (elevated plus maze, open field, light-dark box) GABAergic system modulation : allosteric potentiation of GABA-A observed ex vivo Enkephalin increase (endogenous opioid peptide) and serotonergic modulation Immunomodulatory effects inherited from tuftsin: macrophage activation, T-helper modulation Behavioural models Anxiolysis is measured via time spent in open arms of the elevated plus maze (EPM), visit ratio of central zones of open field , and exit latency in light-dark box

This was relaxed in 2016 and left largely to MP discretion

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In the context of Parkinson's Disease, glutathione has been shown to alleviate symptoms such as tremors, rigidity, and movement difficulties