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While the dithiol mechanism for EcGrx1 and EcRNR or EcPR can be explained by specific protein-protein interactions (Fig

FIGURE 4 While spin traps and nitroxides may possess significant therapeutic potential, their clinical applications may be limited by poor bioavailability and targeting and inadequate BBB penetration (mainly due to low lipophilicity)

It does this by neutralizing free radicals and reducing oxidative stress

Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug

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Microbiol Immunol