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Healthy cells keep this ratio very high, often above 100, which signals a strong antioxidant defense
EGCG may prevent PD by acting as a neurorescue against MPTP-induced impairments in mice and decreasing OS [54]
Studies have demonstrated that lactate-induced autophagy activation can dictate cellular fate between survival and ferroptotic death based on the iron-handling capacity and antioxidant reserve of specific cell types (101,119,148)
doi: 10.1371/journal.ppat.1006139
The design of these compounds mainly involves the replacement of the metal ion with rhodium, nickel, or zinc, or may have an inactive ligand attached, such as 4-ethylphenyl