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To examine the nitric oxide-dependency in this system, the rings were pretreated with 0.03 mM L-NAME, an eNOS inhibitor or 10 M hemoglobin, a nitric oxide scavenger

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Data represented as mean s.e.m

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In an open-label, rater-blinded, single-dose crossover study, IPX203 treatment led to levodopa plasma concentrations larger than 50% of the maximum concentration for 4.6 h compared to 3.9 h with IPX066 accompanied by an increase in good ON-time measured with the Investigator Assessment of Subject's Motor State (5.3 h for IPX203 vs 4.5 h for IPX066) [21]