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In iron-deficient states, GPX4 activity declines, leading to reactive oxygen species (ROS) accumulation and lipid peroxidationpotent triggers of eryptosis (Rochette et al., 2022)

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Mice were percutaneously exposed for 1 h to about 80 S

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Interestingly, while GSH declines in fibrosis, cysteine levels are elevated, suggesting that reduced GSH is primarily due to enzyme dysfunction rather than substrate deficiency [123]