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Available from: [52] UCLA Health [Internet]

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Preservation of glucose-stimulated insulin secretion

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FOXO4-DRIs D-retro-inverso configuration provides exceptional proteolytic stability compared to equivalent L-amino acid senolytic peptides a critical property for cell-based and pre-clinical research where intracellular peptidase activity would rapidly degrade unstable L-amino acid sequences

Flow cytometry was employed to quantify the fluorescence intensity of the various probes, providing precise measurements of mitochondrial function and integrity